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      • Cancer
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      • Autoimmunity
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      • Rapid Patient Testing
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    • Platforms & Automation
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        • M-PVA Magnetic Beads
        New! Cellometer™ Ascend™

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      • Automated Liquid Handling
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      • Integrated Lab Automation
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        New! Cellometer™ Ascend™

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      • Microfluidic Analysis
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      • Detection Solutions
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        New! Cellometer™ Ascend™

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      • Imaging
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      • Sample Homogenization
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        New! Cellometer™ Ascend™

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      • In Vitro Diagnostics (IVD) Platforms & Automation
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      • Instrument Service & Maintenance
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  • Services
    • Preclinical Services
      • Antibody Drug Conjugate Services
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      • Complex Cell Model Screening Services
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      • Base Editing Platform
        • Pin-point base editing platform cell line engineering services
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      • Immune Cell Screening
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      • Cell Panel Screening
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      • Cell Line Engineering
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      • Viral Vector Engineering and Manufacture
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      Preclinical services

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    • Revvity Omics Services
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        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Clinical & Testing Services
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        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Cellular and Humoral Immunoassays
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Tuberculosis Testing Services
        • Oxford Diagnostic Laboratories Service Closures
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Customization Services
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        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Microplate Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Custom Conjugation & Labeling
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        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Radiosynthesis and Labeling
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Licensing
      • Gene Delivery Licensing
        CHOSOURCE expression platform

        Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.

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      • Gene Expression Systems
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        • CHOSOURCE Platform
        CHOSOURCE expression platform

        Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.

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      • Pin-point™ Base Editing Platform
        CHOSOURCE expression platform

        Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.

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      • Virus Screening
        CHOSOURCE expression platform

        Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.

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      CHOSOURCE expression platform

      Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.

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    • Viral Vector Engineering and Manufacture
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        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Lentivirus Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Instrument Service & Maintenance
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        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Equipment Service Plans
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • On-demand Equipment Service
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Customer Training
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      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • OEM Solutions
      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    T-SPOT.TB testing services.

    Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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  • Welcome to Revvity: renowned brands and boundless innovation.

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    Learn about our world-class antibodies for a diverse set of research areas including immunology, neuroscience, cancer, stem cells and cell biology.

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  • HTRF Human Total VAV1 Detection Kit, 10,000 Assay Points

HTRF Human Total VAV1 Detection Kit, 10,000 Assay Points

IFUs, manuals & moreKnowledge base
generic HTRF total primary image
HTRF Human Total VAV1 Detection Kit, 10,000 Assay Points
generic HTRF total primary image
generic HTRF total primary image
generic HTRF total primary image

This HTRF kit enables the cell-based quantitative detection of human total VAV1 (Vav proto-oncogene 1), as a readout of the signaling activity of adaptive immunity receptors, specifically T-cell receptor (TCR) and B-cell receptor (BCR).

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Feature Specification
Application Cell Signaling
Sample Volume 16 µL
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This HTRF kit enables the cell-based quantitative detection of human total VAV1 (Vav proto-oncogene 1), as a readout of the signaling activity of adaptive immunity receptors, specifically T-cell receptor (TCR) and B-cell receptor (BCR).

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Product variants
Unit Size: 500 assay points
Part #:
64VAV1TPEG
List price
USD 2,271.53
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Unit Size: 10,000 assay points
Part #:
64VAV1TPEH
List price
USD 13,214.42
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For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption, and disposal requirements under European REACH regulations (EC 1907/2006).
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USD 13,214.42
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generic HTRF total primary image
HTRF Human Total VAV1 Detection Kit, 10,000 Assay Points
generic HTRF total primary image
generic HTRF total primary image
HTRF Human Total VAV1 Detection Kit, 10,000 Assay Points
generic HTRF total primary image
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Product information

  • Overview
  • How it works
  • Assay validation
  • Simplified pathway
  • Specifications

Overview

VAV1, also known as Vav proto-oncogene 1, is a signaling protein that plays a crucial role in cellular signaling and immune responses. It is primarily expressed in cells of hematopoietic origin, including T cells, B cells, and natural killer cells.

VAV1 acts as a guanine nucleotide exchange factor (GEF) for the Rho family GTPases, including Rac1, Rac2, and RhoA. VAV1 activates these GTPases by promoting the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate) on these enzymes. Through this mechanism, VAV1 is an important regulator of essential cellular processes such as cytoskeletal rearrangement, cell adhesion, proliferation, and migration.

In immune cells, VAV1 is an important intermediary in the downstream signaling of specialized antigen receptors, including T cell receptors (TCRs) and B cell receptors (BCRs). As such, VAV1 has been implicated in several diseases, including the autoimmune disorders systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In these conditions, abnormal VAV1 signaling can contribute to immune dysregulation and inflammation. Additionally, VAV1 is involved in certain types of cancer, where aberrant activation can promote cellular transformation and metastasis.

How it works

HTRF human total VAV1 assay principle

The Total VAV1 assay quantifies the expression level of VAV1 in a cell lysate. Unlike Western Blot, the assay is entirely plate-based, and does not require gels, electrophoresis, or transfer. The assay uses two labeled antibodies, one coupled to a donor fluorophore, the other to an acceptor. Both antibodies are highly specific for a distinct epitope on the protein. In presence of VAV1 in a cell extract, the addition of these conjugates brings the donor fluorophore into close proximity with the acceptor, and thereby generates a FRET signal. Its intensity is directly proportional to the concentration of the protein present in the sample, and provides a means of assessing the protein’s expression under a no-wash assay format.

HTRF Human Total VAV1 assay principle
HTRF human total VAV1 one-plate assay protocol

Detection of Total VAV1 with HTRF reagents can be performed in a single plate used for culturing, stimulation, and lysis. No washing steps are required. This HTS designed protocol enables miniaturization while maintaining robust HTRF quality.

HTRF Human Total VAV1 one-plate assay protocol
HTRF human total VAV1 two-plate assay protocol

The two-plate protocol involves culturing cells in a 96-well plate before lysis, then transferring lysates into a low volume detection plate (either HTRF 384-lv or 96-lv plate) before the addition of the HTRF Total-VAV1 detection reagents. This protocol enables the cells' viability and confluence to be monitored.

HTRF Human Total VAV1 two-plate assay protocol

 

Assay validation

Dose-response of the HTRF Phospho/Total VAV1 assay on cells treated with pervanadate

Jurkat cells (100,00 cells/well) were plated at 25 µL in a 96-well plate in complete culture medium, and treated with 5 µL of increasing concentrations of pervanadate diluted in media, and then incubated for 30 min at 37ºC, 5% CO2.

The cells were lysed with 10 µL of 4x lysis buffer #1 for 45 minutes at RT.  After lysis, 16 µL of lysate were transferred into a low volume white microplate before the addition of 2 µL each of the donor and acceptor HTRF pVav1 or total VAV1 detection reagents.  The HTRF signal was recorded after an overnight incubation.

Dose-response of the HTRF Phospho/Total VAV1 assay on cells treated with pervanadate

 

Simplified pathway

VAV1 signaling pathway

Conformational changes on the intracellular portion of the receptor promote the recruitment of tyrosine kinases Lck and ZAP-70, which phosphorylate its tyrosine domains as well as other neighboring signaling proteins like LAT (Linker for Activation of T cells).

Phosphorylated LAT then recruits VAV1 and promotes its phosphorylation and activation. Phospho-VAV1 goes on to catalyze GDP/GTP exchanges on proteins of the Rho family, especially Rac1 and Cdc42. These Rho proteins then trigger a cascade of downstream signaling events, which include sending transcription factors to the nucleus to promote cytoskeletal reorganization, cell adhesion, migration, and proliferation, as well as other immune-cell mechanisms promoting the elimination of pathogens or compromised cells.

VAV1 signaling pathway

 

Specifications

Application
Cell Signaling
Brand
HTRF
Detection Modality
HTRF
Molecular Modification
Total
Product Group
Kit
Sample Volume
16 µL
Shipping Conditions
Shipped in Dry Ice
Target Class
Phosphoproteins
Target Species
Human
Technology
TR-FRET
Unit Size
10,000 assay points

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HTRF solutions, guide to major applications

This guide provides you an overview of HTRF applications in several therapeutic areas.

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SDS, COAs, manuals and more

Are you looking for technical documents related to the product? We have categorized them in dedicated sections below. Explore now or request your COA/TDS, SDS, or IFU/manual.

IFUs, manuals & more
  • Resource Type
    Manual
    Language
    English
    Country
    -
    Name
    SDS IconManual : VAV1 Total Kit / 64VAV1TPEG-64VAV1TPEH

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