Bispecific antibodies
Unlock the power of dual targeting with our BsAb solutions that can help design, engineer, and optimize your antibody therapeutic to target two distinct sites / markers simultaneously for enhanced efficacy and specificity.
Helping you overcome the challenges seen in dual binding, antibody screening, tissue tropism, pharmacodynamics, analysis, and overall complexity within the process.
Products and Platforms
CHOSOURCE Platform
The CHOSOURCE™ expression platform enables rapid generation of clones expressing high levels of recombinant therapeutic protein during stable cell line development.
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Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability.
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Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
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High Content Screening Instruments
High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level.
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Microfluidic Protein Characterization
Proteins differ from each other in their size, molecular structure, and physiochemical properties.
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Cellular Imaging Software
Revvity offers sophisticated cellular imaging and analysis software to help you acquire, visualize, analyze and share your image data more effectively and efficiently, so you can spend more time discovering.
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In Vivo Imaging
Tracking, monitoring, and visualizing biological processes and disease progression is key to not only helping you better understand biology but also crucial in evaluating the effectiveness of your potential drug candidates earlier in the development process.
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Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
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Content
Addressing the challenges in modern biotherapeutic development
Charter a course to biotherapeutic antibody development success
The rise of bispecific antibodies for use as groundbreaking therapies continues to grow with more than 100 bispecific antibodies currently in development. This is thanks to their remarkable versatility from having dual binding sites targeting two different epitopes, providing advantages such as reducing resistance issues, increased specificity, and identifying unique combinations of drug targets.
However, navigating the intricate challenges of bispecific antibodies is no small feat. That’s why we’ve created this infographic that will aid you on the journey, equipping you with the knowledge to overcome the obstacles along the way and achieve excellence in bispecific antibody development.
Learn more about:
<ul>
<li>Stages that make up the bispecific antibody path</li>
<li>Challenges and considerations faced in development</li>
<li>Various solutions and technologies available</li>
</ul>
<em>For research use only. Not for use in diagnostic procedures.</em>
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Addressing the challenges of bispecific antibody characterization with high-throughput platforms
Bispecific antibodies (bsAbs) have emerged as an attractive class of therapeutic agents with the potential to revolutionize the treatment of various disorders. While the concept of bsAbs has been around for several decades, it has taken time for the technology and understanding of antibody engineering to advance to a point where its practical application has become feasible.
The development of bsAbs demands intricate screening processes to identify candidates with desired binding properties, ensuring they induce specific biological activities. Additionally, achieving optimal tissue tropism and potency requires careful consideration of factors such as antibody size, affinity, and the implementation of innovative characterization strategies.
In this context, this whitepaper explores novel approaches contributing to bsAb characterization, offering real-world examples that highlight their practical applications.
<em>For research use only. Not for use in diagnostic procedures.</em>
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Higher throughput bioanalytical methods accelerate the development and evaluation of advanced biotherapeutics
Successful development of advanced biotherapeutics relies on extensive characterization and tight quality control. Characterizing binding properties of complex biomolecules is a critical step. Biophysical data combined with functional assays are needed to predict efficacy and potency, optimize drug delivery, assess critical quality attributes, and improve biologics drug design.Traditional approaches have limited use in a complex biological environment with multiple interactions. Our speakers have developed and implemented more sensitive and higher throughput technologies:<strong>In this webinar our speakers show:</strong>
<ul>
<li>A method of testing the interaction of a lead biosimilar antibody candidate versus a commercially available antibody</li>
<li>The development of a more sensitive assay to determine the level of binding activity and for QC lot release</li>
<li>An expression platform to aid early-stage clone screening and protein characterization</li>
<li>A higher-throughput platform to streamline cell line development and characterization workflows </li>
</ul>
<strong>Speakers: </strong>
<ul>
<li>Ron Morena, Manager in Analytical Bioassay – Tanvex CDMO</li>
<li>Dr. Neha Mishra, Senior Scientist, BioProduction - Revvity</li>
</ul>
<em>For research use only. Not for use in diagnostic procedures.</em>
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Streamlining the development of bispecific antibodies from expression to quality assessment with Revvity’s biotherapeutic workflow solutions
In this application note we show how the CHOSOURCE™ TnT Transposon Technology was used to express an asymmetric 4-chain bispecific antibody in the CHOSOURCE GS KO host cell line.
Additionally, Revvity’s LabChip GXII Touch HT system is used to rapidly characterize the expressed proteins, showing that in combination with CHOSOURCE, biotherapeutic workflows can be streamlined and accelerated.
<em>For research use only. Not for use in diagnostic procedures.</em>
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Antibody drug conjugates
Revolutionize your therapeutic development with our ADC solutions that can help you discover, develop, and evaluate payload, efficacy and toxicology/safety studies.
Our solutions, including CRISPR tools and screening services, generation of cell models, high-content screening, linker-drug characterization, antibody conjugation, data modelling, potency and detection platforms, and antibody binding and functional assays, can support the precision and reliability required at each stage of your workflow, from discovery through preclinical development.
Products and Platforms
Antibody Drug Conjugate Services
In the discovery of oncology therapeutics, Antibody-drug conjugates (ADCs) are rapidly gaining momentum, with hundreds of candidates advancing through clinical development.
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CHOSOURCE Platform
The CHOSOURCE™ expression platform enables rapid generation of clones expressing high levels of recombinant therapeutic protein during stable cell line development.
Learn more
Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability.
Learn more
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
Learn more
High Content Screening Instruments
High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level.
Learn more
Microfluidic Protein Characterization
Proteins differ from each other in their size, molecular structure, and physiochemical properties.
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Signals
Simplify data capture, processing, and analysis at each ADC development stage, and identify the most promising antibodies, linkers, and payloads.
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pHSense Reagents
Discover a powerful new plate reader tool specifically designed for cell surface target internalization studies for ADC and GPCR research.
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Content
Antibody drug conjugates: A novel targeted approach to cancer therapy
The steady rise in antibody-drug conjugate (ADC) candidates over the past couple of decades reflects the increasing recognition of their potential in
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Preclinical screening platforms for antibody-drug conjugate therapeutics
Antibody-Drug Conjugates (ADCs) are at the cutting edge of oncology research, offering a groundbreaking approach to targeting cancer cells while minimizing damage to healthy tissue.
This white paper explores the latest advancements in ADC development, including innovations in drug delivery, strategies for overcoming treatment resistance, and preclinical screening platforms to optimize efficacy.
If you're looking for insights into the next breakthrough in cancer medicine, this is essential reading.
<em>For research use only. Not for use in diagnostic procedures.</em>
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RNA vaccines and therapeutics
Enhance your RNA therapeutics and vaccine workflows with solutions that can help you produce a safer and efficient approach. With the right support and expertise benefit from the versatility and ease of adaptability a mRNA or other RNA modality platforms can provide.
We can help in target identification, characterization, assay development for early-stage research and screening, as well as preclinical development workflows including evaluation of immunogenicity to support your modality’s efficacy and safety. Our tools and services can address your RNA payload evaluation, optimization and delivery.
Products and Platforms
Microfluidic Nucleic Acid Analysis
Now you can simplify traditional gel separations, while improving the reproducibility of your data in a fraction of the time.
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Lentivirus
Lentiviruses are a subtype of retroviruses which have a single stranded RNA genome that encode for three major structural genes: gag, pol, and env.
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AAV
Our high-quality premade AAV particles are ideal for pilot studies, or as standardized test material for product, process, or assay development.
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RNA Interference
Dharmacon™ siRNA, shRNA, and microRNA-based reagents, leading the field for nearly 30 years providing highly specific and efficient gene silencing.
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Oligonucleotide Custom Synthesis
Leveraging almost 30 years of experience as a leading provider in oligo design and synthesis, Revvity's oligo synthesis team offers a range of services.
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Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
Learn more
Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
Learn more
Content
An emerging therapeutic modality - RNA carves its path out of the paradigm
RNA-based therapeutics have garnered significant attention in recent years, fueled by the success of the mRNA COVID-19 vaccines. The development of therapeutics for a broad range of other conditions, including monogenic diseases, metabolic disorders, and cancer, are now being made possible due to advances in RNA-mediated genome editing tools and technologies.
Considering the growing interest in RNA therapies, our latest article highlights several promising classes of RNA therapeutic, including RNAi, CRISPR, base editing, and mRNA vaccines, as well as the potential to combine RNA technologies with CAR-T.
<em>For research use only. Not for use in diagnostic procedures.</em>
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Rethinking the vaccine landscape
Infectious diseases, which are those caused by pathogenic microorganisms such as viruses, bacteria, parasites, or fungi, have threatened humanity throughout history and are one of the leading causes of death worldwide.1 This is especially the case in low-income countries, often due to the consequences of poverty such as poor nutrition, sanitation, and lack of health education. With the exception of clean, safe water, vaccines are considered one of the best prophylaxes to combat infectious diseases, minimize or prevent transmission, and reduce mortality rates.
<em>For research use only. Not for use in diagnostic procedures.</em>
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Novel RNA therapeutic modalities
Explore the various modalities and advances in therapy that have been enabled by RNA.
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Enabling RNA modalities for therapeutic innovation: Harnessing microfluidic characterization
RNA-based therapeutics, including circular RNA, have gained significant momentum since the COVID-19 pandemic highlighted their potential in vaccine development and other forms of treatment. To date, RNA-based vaccines have garnered much of the spotlight due to their high immunogenicity, rapid development timelines, design flexibility, and higher efficacy against severe disease. However, the broader field of RNA modalities is evolving quickly. To keep pace with this progress, various technologies are being leveraged to evaluate the efficacy and safety of these therapeutic approaches.
In this on-demand webinar, Revvity’s James White, PhD, R&D Assay Development Lead, and Dipti Mehta, Senior Application Scientist, will explore microfluidic platforms for characterizing circular nucleic acids and other major isoforms with a high degree of reproducibility, sensitivity, and throughput.
Covering:
<ul>
<li>New advances and analytical challenges in RNA modalities for therapeutics</li>
<li>RNA analysis using the LabChip™ GXII Touch™ Characterization system</li>
<li>Methods for analyzing new RNA modalities</li>
<li>Plasmid DNA analysis with the LabChip pDNA assay </li>
</ul>
<em>For research use only. Not for use in diagnostic procedures.</em>
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