Explore our solutions
Target identification and validation
In the intricate dance of discovery, target identification and validation serve as the opening act, laying the groundwork for development of transformative therapies. This sub-category delves into the sophisticated tools and strategies employed to uncover and affirm the gene(s) responsible for disease pathology. By combining advanced genomic biomarkers, panel strategies, and high-throughput screenings, we offer a panoramic view of the genetic landscape, assisting the selection of targets. Our rigorous validation processes support the selection of genetic targets that are not only relevant but also viable for the development of targeted therapies, helping you set a robust foundation for potential successful therapeutic outcomes.
Discover how our CRISPR and base editing tools can fast-track your gene therapy development from target identification to optimization.
Automated Liquid Handling
We've been providing liquid handling solutions for over 40 years to help labs accelerate their science.
Multiomics and TotalSeq Reagents by BioLegend
Multiomics provides unparalleled protein and genetic analysis. Explore how our TotalSeq™ reagents can be integrated into your existing workflows and expand your capabilities.
Biological mechanism of action
Understanding the biological mechanism of action is akin to deciphering the language of cells and genes. This sub-category focuses on unraveling the complex interactions and pathways that underpin disease processes, from receptor-ligand binding to gene expression regulation. Armed with robust validated cell lines, reporter gene cassettes, and multimode detection solutions, we dissect the nuances of biological pathways, offering insights that can drive the development of targeted therapies.
Understand the biology behind disease with our advanced cell-line engineering, multimode detection assays, and high-content imaging solutions.
Cell Line Engineering
Project updates are provided at regular intervals with validation and QC performed throughout prior to shipping the final clone and parental line alongside the full data pack.
Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
Imaging
Imaging is a powerful technology for accelerating our understanding of biology and disease - and transforming human health.
Cell Painting
Cell painting is a type of phenotypic assay and a powerful application of high-content screening.
Gene editing
Explore the cutting edge of gene editing, where, in our research, we employ sophisticated delivery methods like adeno-associated viruses (AAV), lentiviruses (LV), and nanoparticles to target and correct disease-causing genes. Our rigorous practices help enhance the safety and efficacy of these vectors, navigating the complexities of in vivo gene therapy, from overcoming immune responses to crossing the blood-brain barrier.
Leveraging CRISPR-Cas9 and innovative base editing technologies, we offer enhanced specificity in DNA modification, tackling rare genetic disorders with new hope. Despite challenges like off-target effects and DNA damage, our advanced solutions, including the Pin-point™ base editing platform, are overcoming barriers, marking a new era in gene therapy. Join us in this journey of discovery and healing, where gene editing opens doors to transformative treatments.
Explore how our advanced gene editing technologies can help overcome barriers and drive the development of safer, more effective therapies.
CRISPR Technologies
CRISPR-Cas9 genome engineering technologies hold great promise for understanding diseases and for the development of life saving treatments.
Dharmacon Reagents
Explore a complete range of genomic solutions from single-gene experiments to whole-genome screens.
Viral Vector Products
Viral vectors are the most efficient vehicles for gene delivery into a specific cell type or tissue for a wide array of research purposes.
Viral Vector Engineering and Manufacture
Individualized and customized solutions tailored to fit viral vector projects at all stages of discovery and development, ensuring fast and cost-effective product manufacture.
Lentivirus
Lentiviruses are a subtype of retroviruses which have a single stranded RNA genome that encode for three major structural genes: gag, pol, and env.
Lentivirus Services
Lentivirus is an efficient tool for fast, efficient, and cost-effective generation of stable homogeneous cell models for strong gene expression or gene knockdown.